Dee Cee Labs Formula 303 Review – 10 Facts To Consider

This review is medically reviewed or fact checked to ensure factually accurate information.

With strict editorial sourcing guidelines, we only link to reputable media sites, academic research institutions and, when research is available, medically peer-reviewed studies. Note that an extensive list with all used Sources is available at the end of the review.

The information in our reviews is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice.

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During our in-depth Dee Cee Labs Formula 303 review, we will answer frequently asked questions about this dietary supplement. Our assessment will also analyze the core ingredients, potential side effects, if the product works, effectiveness, claimed benefits, price, and best stores to purchase from.

This product is one of the most popular supplements in the United States, and we believe that an extensive Dee Cee Labs Formula 303 review is needed for those looking to learn more about the pros and cons of this supplement.

What Is Formula 303?

Dee Cee Labs Formula 303 is a high potency all-natural relaxant. According to Dee Cee Labs’ official website, this formula is highly effective for those with difficulty sleeping, snoring, or restlessness. 

The formula consists of a mixture of valerian and Passiflora (Passionflower) extracts, both trendy ingredients in stress, anxiety, and sleep support supplements.

Who Makes It?

Dee Cee Labs is a U.S. company founded in 1962 by Harry F. Hester, “to help people aim for a healthier life through sound and quality nutritional vitamins, minerals, and supplements.”

While Formula 303 is Dee Cee Labs’ most popular product, the company makes a host of other dietary supplements including 5-HTP 100 mg, Maxi Snooze, St. John’s Wort, Q10 Ultra, Unique B12, Ultra V.M., or Formula 182 Black Cohosh

Every ingredient used in Dee Cee Labs formulas goes through an extensive Quali Pure Standards (QPS) control system, which guarantees 100% identity, purity, strength, and composition testing of incoming raw materials and finished products. 

Dee Cee Labs contact information:

  • Address: 304 Dee Cee Road, White House, TN 37188
  • Email:
  • Phone: 1 (800) 251-8182
  • Website:

Dee Cee Labs Formula 303 Ingredients

Formula 303 contains the following active ingredients: six parts Valerian root extract (Quad-Strength), three parts Passiflora extract (Quad-Strength), and one part Magnesium carbonate.

How Valerian Helps You Relax and Sleep Better

Valerian (Valeriana officinalis) is a flowering plant native to Europe and parts of Asia and also grows in North America. Valerian root’s use dates back to the Roman and Greek Empires and was noted by Hippocrates to treat heart palpitations, nervousness, headaches, and trembling.

In modern times, Valerian root extract is usually used for sleep disorders, mainly the inability to sleep (insomnia). It is also used for psychological stress and anxiety, but limited scientific research supports these uses.

Valerian contains a substance known as valerenic acid believed to affect gamma-aminobutyric acid (GABA) receptors in the brain. It is thought that one of the purposes of GABA is to control anxiety or fear experienced when nerve cells are overexcited. By doing so, valerian may act as a mild sedative and anxiolytic.

Valerian extract may also benefit other conditions, but the amount of research available is limited. Either way, some studies suggest that valerian root can bestow benefits for:

  • Menstrual problems – women who experience painful menstruation or premenstrual syndrome (PMS) may benefit from valerian. One research found it improved the behavioral, emotional, and physical symptoms of PMS.
  • Menopause – one clinical trial in menopausal women observed notable reductions in hot flash severity and average drops in hot flash frequency during two months of treatment with 765 mg of valerian daily.
  • Parkinson’s Disease – a study found that treating mice with Parkinson’s Disease with valerian extract led to increased antioxidant levels, decreased inflammation, and better overall behavior.
  • Restless Legs Syndrome – a two-month clinical trial in people with restless legs syndrome concluded that using 800 mg valerian per day improved symptoms and diminished daytime sleepiness.

Passionflower Benefits

Passionflower (Passiflora Incarnata) is a perennial climbing vine native to southeastern North America. The plant has been used historically in treating anxiety, insomnia, seizures, and hysteria.

Although passionflower’s safety and effectiveness have not been adequately studied, evidence from limited animal and human research suggest that the Passionflower extract may help treat anxiety, insomnia, and nervous disorders.

In a trial published in Phytotherapy Research, subjects received a daily dose of herbal tea with purple passionflower. After one week, participants showed improvements in their sleep quality. The trial concluded that low amounts of purple passionflower might help adults manage mild sleep irregularities.

Formula 303 Side Effects & Warnings

Valerian root extract is likely safe for most adults when taken as recommended, short-term. Valerian has been used with apparent safety in studies lasting up to 28 days. The safety of the long-term hasn’t appropriately been assessed yet.

Valerian may cause heart disturbances, uneasiness, stomach upset, headache, excitability, mental dullness, insomnia. Some people feel sluggish in the morning after taking valerian, especially at higher doses.

Discontinuing valerian after long-term use may cause withdrawal symptoms. To avoid possible adverse effects when discontinuing valerian after long-term use, it’s best to decrease the dose slowly over a couple of weeks before stopping completely.

When taken by mouth, passionflower is likely safe for most people when used in food-flavoring quantities. It is possibly safe for most people when consumed as a tea nightly for seven (7) nights or in a dietary supplement for up to two (2) months. 

Passionflower may cause adverse effects in some users, such as confusion, dizziness, and drowsiness.

How Much Does Formula 303 Cost?

Formula 303 is available in three different packagings:

  • 45 tablets bottle at $15.99
  • 90 tablets bottle at $23.99
  • 250 tablets bottle at $41.99 (best deal)

Formula 303 Review – Pros & Cons


  • Over 6,000 positive reviews and ratings on Amazon;
  • A proven formula that has been around for many years;
  • Wide range of potential benefits, from muscle pain and spasms to stress and anxiety;
  • Gluten-Free, Non-GMO product
  • It contains valerian root, a widely used herbal extract for its relaxant properties.


  • The label could be more informative and list the exact amount of each ingredient;
  • A lot more research is needed to asset the full range of Passiflora’s benefits.

Where To Buy Formula 303?

Formula 303 natural relaxant supplement is available for purchase from Dee Cee Labs’ official website or various online stores. From what we could find, the best price (for all three available packages) is offered by Amazon.

Customer Testimonials

Salvation for spasms and pain ~ I was first offered this product through my chiropractor after I’d had a horrible car accident, and I have continued to use Formula 303 for over 15 years with great relief. It’s strong without interfering with daily chores and […] Read full review

I was first introduced to this through my prolotherapy physician. One of his medical peers sold it when he was in town treating patients. He suggested I try it for muscle tightness due to tension. To be honest, Formula 303 has been […] Read full review

My wife’s chiropractor suggested this supplement as a muscle relaxer. She got it and said that it worked, so I tried it, and worked wonderfully for me. I will caution you, though. It SEEMS that if I take it every day it […] Read full review

Similar Supplements

Before we conclude our Formula 303 review, let’s take a quick look over several other similar brain supplements that may be good alternatives for those who are not convinced by the benefits offered by the formulation developed by Dee Cee Labs.

Maximum Strength Sleep-Aid made by Wellness Basics is another high potency nighttime sleep aid. This non-habit forming formula contains 50 mg of Diphenhydramine HCI and is available as liquid softgels for faster absorption.

Muscle Cramp/Tension Formula made by Pure Encapsulations is advertised as a potent, hypoallergenic muscle cramp and tension release formula. It contains Passionflower (100 mg), Magnesium (150 mg), Calcium (50 mg), Lemon balm (50 mg) and Chamomile (50 mg). The formula is free from artificial sweeteners and colors, gluten, egg, wheat, peanuts, hydrogenated fat, magnesium stearate, and other unnecessary excipients. 

Magnesium Complex made by Nobi Nutrition is advertised as a premium magnesium supplement for sleep, stress & anxiety relief, leg cramps, headaches, energy, and muscle relaxation. It’s one of the best selling magnesium-based dietary supplements on Amazon with 10,000+ real customer reviews and an outstanding rating of 4.8 out of 5 stars.

Bottom Line

If you are experiencing restlessness or sleep issues, then Dee Cee Labs Formula 303 can help you manifolds. However, with any sleep-inducing dietary supplements, you need to be careful of the addiction that can happen in the long-term.

If all you want is to improve your sleep quality, we insist on first resorting to natural options. A good exercise of about 30 minutes each day, four to five days a week, will go a long way to reduce sleep irregularities and relax your mind. If you still don’t get any relief, you may use Formula 303 and see if it works well.

In the end, more important than all “technical stuff” around this formula is what real users say about Formula 303. And the reviews and testimonials we saw online are overwhelmingly positive, which is an excellent sign that this dietary supplement may work as advertised.

Frequently Asked Questions

Dee Cee Labs Formula 303 is advertised as safe with no potential dangerous adverse effects. However, the two core ingredients – Valerian and Passiflora – are not recommended for long-term use. Both plant extracts are associated with rare side effects, including headaches, stomach upset, mental dullness, excitability, uneasiness, heart disturbances, insomnia, drowsiness, dizziness, or confusion.

Dee Cee Labs Formula 303 contains six parts Valerian root extract (Quad-Strength), three parts Passiflora extract (Quad-Strength), and one part Magnesium carbonate.

No, this supplement doesn’t make you sleepy. Formula 303 is a non-habit forming natural supplement designed for those with difficulty sleeping, snoring, or restlessness.

Formula 303 reviews on Amazon, as of February 2021, are overwhelmingly positive, with 89% of the customers ranking this supplement with four (4) stars or higher. Out of 3,309 customer reviews, here’s how this nootropic supplement ranks: 

  • 5 star – 81%
  • 4 star – 9%
  • 3 star – 4%
  • 2 star – 2%
  • 1 star – 3%

Adults and children 12 years of age and older take as recommended or directed by your doctor or pharmacist. Do not exceed 12 tablets in 24 hours. For muscle spasms, take two (2) tablets every three hours until relief is obtained.


  • Dee Cee Labs official website. Retrieved on February 1, 2021. [Source]
  • Stephen Bent, Amy Padula, Dan Moore, Michael Patterson, and Wolf Mehling – Valerian for Sleep: A Systematic Review and Meta-Analysis. Published on April 13, 2015. Retrieved on February 1, 2021. [Source]
  • Valerian. National Institute of Health. Retrieved on February 1, 2021. [Source]
  • Brent A. Bauer – Valerian: A safe and effective herbal sleep aid? Published on February 15, 2018. Retrieved on February 1, 2021. [Source]
  • Cathy Wong – The Health Benefits of Valerian Root. Retrieved on February 1, 2021. [Source]
  • K. Murphy, Z. J. Kubin, J. N. Shepherd, and R. H. Ettinger – Valeriana officinalis root extracts have potent anxiolytic effects in laboratory rats. Published on December 29, 2009. Retrieved on February 1, 2021. [Source]
  • Lisa M. Del Valle-Mojica and José G Ortíz – Anxiolytic properties of Valeriana officinalis in the zebrafish: a possible role for metabotropic glutamate receptors. Published On August 24, 2012. Retrieved on February 1, 2021. [Source]
  • Valerian – Retrieved on February 1, 2021. [Source]
  • Ji Hyun Baek, Andrew A. Nierenberg, and Gustavo Kinrys – Clinical applications of herbal medicines for anxiety and insomnia, targeting patients with bipolar disorder. Published on June 19, 2014. Retrieved on February 1, 2021. [Source]
  • Zohra Ashpari – The Calming Effects of Passionflower. Retrieved on February 1, 2021. [Source]
  • Passionflower – Retrieved on February 1, 2021. [Source]
  • Passionflower – National Center for Complementary and Integrative Health (NCCIH). Retrieved on February 1, 2021. [Source]
  • R. Sathish, Alok Sahu, and K. Natarajan – Antiulcer and antioxidant activity of ethanolic extract of Passiflora foetida L. Published in June 2011. Retrieved on February 1, 2021. [Source]
  • A. Ngan and R. Conduit – A double-blind, placebo-controlled investigation of the effects of Passiflora incarnata (passionflower) herbal tea on subjective sleep quality. Published on February 3, 2011. Retrieved on February 1, 2021. [Source]

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