Thorne Research Q-Best 100 Review – A Top of the Line CoQ10 Supplement?

This review is medically reviewed or fact checked to ensure factually accurate information.

With strict editorial sourcing guidelines, we only link to reputable media sites, academic research institutions and, when research is available, medically peer-reviewed studies. Note that an extensive list with all used Sources is available at the end of the review.

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Thorne Research Q-Best 100 is a patented crystal-free CoQ10 supplement for healthy heart function. The formula also offers nutritional support for a healthy nervous system. Q-Best 100 is produced by Thorne Research, a reputable U.S. company based in Sandpoint, Indiana.

Quick Overview

According to Thorne Research, this unique formula was designed for optimal absorption. It’s better absorbed than other similar CoQ10 supplements and up to three times better than Ubiquinol. 

Q-Best 100 – just like every Thorne Research product – is made with the purest possible ingredients. The formula doesn’t contain gluten or other major allergens (eggs, tree nuts, peanuts). This product also contains no yeast, shellfish, dairy, or fish.

Everything about Thorne Research

Thorne Research Inc. is a U.S. based company that manufactures a wide range of dietary supplements – circulatory, detoxification, endocrine, cognitive, sleep, musculoskeletal, gastrointestinal, immune, and neurological support products, as well as aging, minerals, antioxidants, fatty acids, vitamins, veterinarian, proteins, women’s, and men’s health products. 

Some of Thorne Research’s most popular dietary supplements include Vitamin D-5000, Stress B-Complex, 5-MTHF 1 mg Folate, Basic B Complex, Zinc Picolinate 15 mg, Meriva 500-SF, and Berberine-500.

Contact information:

  • Address: 25820 Highway 2 West Sandpoint, ID 83864, United States;
  • Phone: (800) 228-1966;
  • Website:

Thorne Research Q-Best 100 Ingredients

Thorne Research Q-Best 100 contains the following core ingredients: Coenzyme Q10 100 mg.

Inactive ingredients include gelatin (bovine source), purified water, glycerin (vegetable source), lycopene and turmeric (color) gelcap, conjugated linoleic acid, flaxseed oil, and soy monoglycerides.

Coenzyme Q10 – CoQ10 functions as a potent intracellular antioxidant; due to its involvement in cellular energy production, Coenzyme Q10 affects each cell’s function in the body, making it an essential nutrient for the health of all tissues and organs. 

CoQ10 mainly benefits the most metabolically active organs and systems: gingiva, heart, gastric mucosa, and immune system. An adequate supply of CoQ10 is essential to heart muscle health as it supports healthy heart rhythm and can help regulate blood pressure.

Our bodies naturally produce Coenzyme Q10, but as we grow older – especially after the age 40 – its production begins to reduce to such a level that by the time we are in our sixties, CoQ10 levels are only about 10% of what they were when we were in our thirties. 

Supplementing with a high-quality Coenzyme Q10 supplement (like Q-Best 100) can help restore and replenish this shortfall and provide significant benefits for our health, at a time in individuals’ lives when they need it most.

Q-Best 100 Benefits

Most CoQ10-based supplements are formulated in a crystal (dry powder) form. However, this crystalline form alone is not well absorbed because these crystals do not efficiently dissolve in the intestines. When crystals are mixed in a lipid-based delivery system (i.e., oil-based soft gels), absorption is improved.

Thorne Research Q-Best 100 provides CoQ10 in a crystal-free, fully dissolved lipid-based form, allowing better absorption by the intestinal mucosa. A tri-lipid delivery system accomplishes this.

One lipid acts as a carrier molecule to facilitate absorption; the second lipid keeps the CoQ10 crystals dissolved at 10°C above body temperature; while the third holds the CoQ10 crystals fully dissolved below body temperature. 

Clinical trials demonstrate superior absorption by a tri-lipid delivery system over other preparations. 

Also, a CoQ10 bioavailability study showed the absorption of Q-Best to be vastly higher than crystalline forms of CoQ10, including liposomal, nanoparticle, and oil suspension liposomal preparations. 

Thorne Research Q-Best 100 Reviews

I was introduced to Thorne products by a doctor. I valued her opinion, and when I ran out, I went directly to Amazon to place an order. The product arrived  […] Read full review

I’ve been using this supplement for two years. I will continue to include it in my daily routine to prevent muscle fatigue and cardiovascular health. […] Read full review

This is the BEST CoQ10 I’ve ever used. To say the least, it’s not cheap, but you get what you pay for. Check out […] Read full review

How To Take Thorne Research Q-Best 100

The recommended dose is one gel cap, preferably in the morning with water, once or twice daily. Pregnant or nursing mothers should not take Q-Best 100 unless expressly advised by a healthcare practitioner.

Side Effects & Warnings

Thorne Research Q-Best 100 is all-natural and safe. According to Thorne Research, there are no side effects associated with the use of their supplement. 

Q-Best 100 contains Coenzyme Q10, which is likely safe for most adults when taken as recommended.

While most people tolerate Coenzyme Q10 well, it can cause some mild side effects, including stomach upset, vomiting, loss of appetite, nausea, allergic skin rashes, and diarrhea. It also might lower blood pressure, so check your blood pressure carefully if you have low blood pressure.

Price – Is It Too Expensive?

The retail price for Thorne Research Q-Best 100 is $43.00 (60 gelcaps bottle). The product is widely available online, and it can be purchased from either Thorne Research official website or several online stores such as:

  • Amazon – $43.00 (including free shipping for orders from within the United States);
  • iHerb – $43.00;
  • NHC – $41.00 (autoship available);
  • Pure Formulas – $43.00 (including free shipping).

Similar Dietary Supplements

There may be several good alternatives to Thorne Research Q-Best 100. Some of these alternatives include:

CoQ10 produced by Purely Holistic – this popular CoQ10 supplement has over 2,100 customer reviews on Amazon, with an average rating of 4.7 out of 5 stars. 

CoQ10 claimed benefits include:

  • Easy to swallow softgels;
  • Better absorption;
  • 100% natural formula, side effects free;
  • Excellent for heart health.

Ubiquinol with Kaneka QH produced by Doctor’s Best – this high-rated dietary supplement is made by one of the top supplement companies in the United States.

Ubiquinol with Kaneka QH claimed benefits include:

  • Ubiquinol has potent antioxidant actions in target cells;
  • Supports mitochondria to enhance cellular energy production;
  • Promotes healthy heart functioning;
  • Non-GMO, Gluten-Free, Soy Free.

CoQ10 120 mg produced by Pure Encapsulations – this is another excellent alternative. While more expensive than other similar dietary supplements, Pure Encapsulations’ formula distinguishes itself through ingredients’ quality.

CoQ10 120 mg claimed benefits include:

  • Contains only pure, premium ingredients;
  • A hypoallergenic, research-based formula that is designed to deliver predictable and desired results;
  • Enhanced cellular energy;
  • It supports all body cells and is incredibly supportive of tissues that require a lot of energy, such as periodontal tissue, the heart muscle, and the body’s natural defense system cells.

Our Bottom Line

Suppose you have any heart health concerns or even family history. In that case, CoQ10 should be one of the nutritional supplements in your daily regimen. Thorne Research Q-Best 100 is a safe and effective CoQ10 product for regulating high blood pressure, cardiovascular support, protection against free radicals, and boosting the immune system. 

While it shows promise for treating low CoQ10 levels associated with age and statin medications, it should not be used by individuals with known soy allergies as it contains monoglycerides derived from soy and can cause a hypersensitivity reaction.

Frequently Asked Questions

Q-Best 100 is a patented crystal-free CoQ10 supplement for healthy heart function.

Q-Best 100 can be purchased from several online retailers such as:

  • Amazon US
  • NHC
  • Pure Formulas
  • iHerb
  • Thorne Research

The retail price for Q-Best 100 is $43.00 (60 gelcaps bottle). Some online stores may offer discounts, VIP autoship, or free shipping on specific orders.

Q-Best 100 – as any other dietary supplement – can be purchased without a prescription.

The formula is advertised as 100% natural and safe to take. However, Coenzyme Q10 has been associated with several mild side effects such as stomach upset, vomiting, loss of appetite, nausea, allergic skin rashes, and diarrhea.

While most consumers are happy with the results, some users have complained about the inclusion of GMO soy as an inactive ingredient.

This formula is not supposed to support cognitive health. According to Thorne Research, the product was designed to help heart health and support the healthy nervous system.

No, Q-Best 100 is not recommended for children.

Pregnant or nursing mothers should not take Q-Best 100 unless expressly advised by a healthcare practitioner.

The recommended dose is one gel cap, once or twice daily, preferably in the morning with water.

Thorne Research produces this dietary supplement.

To return the product and get your refund, you need to follow the steps below: 

  • Make sure you’ve purchased the product from an authorized reseller.
  • Save the original receipt and the original bottle(s) with any unused product. 
  • Contact customer support for assistance in processing your return.

There are several ways of contacting Thorne Research customer support. First, is by using their Contact Us form available on the official website. You can also call them directly at (800) 228-1966 Monday-Friday 9:00 AM – 7:00 PM (E.T.).

The core ingredient in Q-Best 100 is Coenzyme Q10.


  • Q-Best 100 Amazon webpage. Retrieved on February 1, 2021. [Source]
  • López-Lluch G., Del Pozo-Cruz J., Sánchez-Cuesta A., Cortés-Rodríguez A. B., and Navas P. – Bioavailability of coenzyme Q10 supplements depends on carrier lipids and solubilization. Published on June 27, 2018. Retrieved on February 1, 2021. [Source]
  • Ikematsu H., Nakamura K., Harashima S., Fujii K., and Fukutomi N. – Safety assessment of coenzyme Q10 (Kaneka Q10) in healthy subjects: a double-blind, randomized, placebo-controlled trial. Published on January 23, 2006. Retrieved on February 1, 2021. [Source]
  • Official Thorne Research website. Retrieved on February 1, 2021. [Source]
  • Flowers N., Hartley L., Todkill D., Stranges S., and Rees K. – Co-enzyme Q10 supplementation for the primary prevention of cardiovascular disease. Published December 4, 2014. Retrieved on February 1, 2021. [Source]
  • Maes M., Mihaylova I., Kubera M., Uytterhoeven M., Vrydags N., and Bosmans E. – Lower plasma Coenzyme Q10 in depression: a marker for treatment resistance and chronic fatigue in depression and a risk factor to cardiovascular disorder in that illness. Published in 2009. Retrieved on February 1, 2021. [Source]
  • Coenzyme Q10 – Retrieved on February 1, 2021. [Source]

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