Symplex F Review – 12 Facts To Consider

This review is medically reviewed or fact checked to ensure factually accurate information.

With strict editorial sourcing guidelines, we only link to reputable media sites, academic research institutions and, when research is available, medically peer-reviewed studies. Note that an extensive list with all used Sources is available at the end of the review.

The information in our reviews is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice.

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This updated Symplex F review will answer some of the most frequently asked questions about this supplement. We will analyze all the details behind the manufacturer, Standard Process, while also reviewing the core ingredients and their indispensable role in the overall formulation. 

Another essential aspect analyzed during the review is the benefits of glandular supplements. Glandular products have been used by health experts for almost a century to support all major organ systems.

What Is Symplex F?

Symplex F, made by Standard Process, is a unique dietary supplement designed to support normal hormonal balance in women. Good hormonal balance is vital in every stage of a women’s life. 

According to Standard Process, Symplex F supports the ovaries’ healthy function and the adrenal, pituitary, and thyroid glands. This formula provides uniquely derived nucleoprotein-mineral extracts that improve cellular health.

Some claimed benefits include:

  • Supports healthy function of the ovaries;
  • Promotes hormonal balance in women;
  • Maintains healthy pituitary and thyroid gland;
  • Supports adrenal health;
  • Supports cellular health;
  • It provides uniquely derived nucleoprotein-mineral extracts.

Everything About Standard Process

Symplex F is made by Standard Process, a US company founded in 1929 by Dr. Royal Lee.  There was a a lawsuit in 2018. The jury awarded $5.5 million to the plaintiff, who sued after purchasing one of SPL’s products, “Cholestin.”

According to the company, all their dietary supplements include foods prepared to safeguard their nutritional value. Standard Process sources its ingredients locally from certified organic farms. 

The whole food ingredients are then used in various dietary supplements that may include animal tissue extracts, whole food extracts, botanicals, concentrates, whole food isolates, and synthetic ingredients. 

These highly elaborate mixtures comprise many elements designed to trigger trophic effects that maintain the body’s healthy balance and wellness.

Besides Symplex F, Standard Process also makes other popular supplements like Cataplex G (supports the nervous system), Cruciferous Complete (detoxification and antioxidant), Catalyn (multivitamin for general wellbeing), Tuna Omega-3 Oil (for the brain, heart, eye, and skin), Congaplex (for the immune system), Ferrofood (iron supplement), Cyruta Plus (cholesterol support), and Ligaplex II (for bone health).

Standard Process contact information:

  • Address: 1200 W. Royal Lee Drive, Palmyra, WI 53156
  • Phone: 800-848-5061 (toll-free) / 262-495-2122 (local)
  • Email:

Customer Support Department

  • Phone: 800-558-8740
  • Fax: 800-438-3799
  • Email:

Symplex F Ingredients

Symplex F contains the following active ingredients per serving (1 tablet): Calcium 20 mg and Proprietary Blend [Magnesium citrate, bovine pituitary PMG extract, bovine adrenal PMG extract, bovine ovary PMG extract, and bovine thyroid PMG extract (processed to remove its thyroxine substantially)] 135 mg.

Inactive ingredients include calcium lactate, cellulose, and calcium stearate.

What Are Adrenal Extracts?

The glands of animals like pigs and cows are collected from slaughterhouses and, through specific technological processes, are made into adrenal extracts. For these extracts, it’s used either the outer parts or the whole gland. 

The resulting extract contains one core ingredient – hydrocortisone (the name given to cortisol when supplied as a medication).

At the beginning of the twentieth century, adrenal extracts were utilized for various purposes and were mostly available as an injection. They were used to treat:

  • allergies
  • burns
  • Addison’s disease
  • morning sickness
  • surgical shock
  • asthma

As better medications were developed, they mostly fell out of use. Today, companies don’t make adrenal extracts into injections anymore. The extracts are available only in pill form. 

The US Food and Drug Administration (FDA) banned imported adrenal extract in 1989. A few years later, in 1996, it recalled injectable extracts too. 

The FDA also issued public alerts against the use of adrenal extract after finding that more than 80 people contracted infections from contaminated products. 

Please note that the FDA does not control these supplements in the pill form and won’t intervene until dangers are identified.

How Does Symplex F Work?

Symplex F works by supporting four or your body’s major systems.

1) Promotes healthy thyroid function

By enabling the building blocks needed for proper thyroid gland function, this dietary supplement supports the thyroid gland’s capacity to improve the protein synthesis rate in most tissues and maximize the potential of all food types for energy production.

2) Promotes the healthy functioning of the adrenal glands

Most major body systems are impacted in some way by the actions of the adrenal glands. The adrenal glands play a crucial role in blood sugar, hematological, carbohydrate metabolism, hormone production, anti-inflammatory agent production, and liver function.

Adrenal glands are also involved in pulmonary, central nervous, cardiovascular, and gastrointestinal system functions. They are intimately related to adjustments the body makes in response to emotional and stress changes.

3) Supports healthy pituitary function

The pituitary gland is commonly referred to as the “master gland” because it stores and secretes several hormones that regulate essential bodily processes. For example, the pituitary gland directly influences protein synthesis and cell division for growth and oversees various metabolic activities involving thyroid and adrenal gland function. 

The pituitary gland also stimulates the production of gonadotrophic hormones in both men and women, essential for reproduction and lactation.

4) Supports healthy ovarian function

Estrogen improves the reproduction and growth of specific cells in the body responsible for developing most female secondary sexual characteristics.

Symplex F Review – Pros & Cons


  • Standard Process is a company with a long tradition of making high-quality dietary supplements;
  • Overwhelmingly positive reviews and testimonials;
  • Uses premium quality ingredients synthesized during a low-temperature, high-vacuum drying technique;
  • Affordable hormonal balance supplement at just $64.50 for 360 servings.


  • Magnesium citrate and bovine (cow) hormone efficacy and safety are not thoroughly studied;
  • Most of the formula, excepting calcium, is hidden behind a proprietary blend, so there’s no way of telling how much of each ingredient is in the formulation.

How Much Does Symplex F Cost?

Symplex F is relatively inexpensive compared to other supplements for hormonal balance. One 90 tablets bottle (90 servings) costs $18.50, and one 360 tablets bottle (360 servings) costs $64.50.

These are the list prices. You may find better prices, depending on the store or time of year (sometimes the product goes on sale).

Where To Buy From?

Symplex F is widely available in online stores like NHC, eBay, The Wellness Shoppe, or Holistic Heal International and available from most health professionals in your area. 

However, we recommend buying the product from Standard Process directly as they seem to offer the best deals. On top of that, they have a handy tool that helps you find a nearby healthcare professional who can give personalized Standard Process supplement recommendations.

Other Related Articles

Standard Process Lawsuit

Does Symplex F Increase Estrogen?

Does Symplex F Help With Weight Loss?

Customer Testimonials

I have been taking this product for five years. An acupuncturist prescribed it for me for hot flashes. I started with one tablet, three times a day, and gradually reduced it to one tablet a day. It lessened the hot flash intensity and frequency.

I used this product after I consulted with a physician about my hormone imbalance to improve my health. I recommend using this product if you are trying to get healthy & balance your hormones. However, I recommend consulting a professional to establish precisely what are the best supplements you need!

Symplex F was recommended to me by a naturopath when I expressed concern about my libido decreasing all of a sudden. This supplement has restored my sense of well being and interest in sex. I am in good health, and I am a 65-year-old woman.

Symplex F Side Effects & Warnings

Symplex F is advertised as safe to use. However, because most of the ingredients are hidden behind a Proprietary Blend, and there is no way of telling how much of each ingredient was used in this product, we recommend caution when taking Symplex F.

For instance, typical side effects of magnesium citrate (even in lower amounts) may include:

  • nausea
  • vomiting
  • abdominal cramping
  • electrolyte imbalance
  • diarrhea
  • gas (flatulence)
  • hypermagnesemia (increased levels of magnesium in the blood)

Are There Better Options?

Before we conclude our Symplex F review, let’s take a quick look over several other similar dietary supplements that may represent a good alternatives for those who are not convinced by the benefits of this formulation.

Adrenal Health made by Gaia Herbs can be a more natural alternative to supplements using PMG extracts. Adrenal Health combines Ashwagandha root extract with other physically and emotionally supporting adaptogen herbs to nourish the adrenals to support a healthy stress response.

Thyroid Maintenance made by Dr. Christopher’s is another interesting herbal thyroid support supplement. The formula is based on a proprietary blend of organic herbal extracts that include Kelp, Mullein Leaf, Parsley Leaf, Irish Moss, Sheep Sorrel, Wildcrafted Watercress, and Wildcrafted Nettle Leaf. 

a-Drenal made by RLC is an adrenal support for stress relief & energy supplement, and an interesting alternative to Symplex F. It includes a variety of ingredients, starting with several potent herbs and ending with Pantothenic acid and L-Theanine. According to RLC, this supplement is formulated to promote calm physical & mental energy and support adrenal function by maintaining healthy cortisol &blood sugar levels.


One thing Symplex F has is how well-received this supplement is. While not abundant, the reviews and testimonials available online are overwhelmingly positive. How real customers see the product is a huge factor in determining if the formula is effective or not. 

From a cost per serving perspective, Symplex F is affordable compared to other hormonal support supplements. 

The only issue we have with this product is the proprietary blend of bovine PMG extracts. First, there’s no way of telling how much of each ingredient was added to the formulation. Secondly, the safeties and efficacy of PMG extracts haven’t been thoroughly studied and understood. 

Modern hormonal support supplements use safer ingredients – usually herbal extracts with proven benefits for overall health.

In conclusion, we recommend caution before taking Symplex F. Your healthcare provider may be able to suggest better alternatives or, at the very least, provide personalized supplement recommendations.

Frequently Asked Questions

The recommended starting dose for adults is one (1) tablet per meal, or as directed.

Symplex F is a dietary supplement formulated to supports the healthy function of the ovaries and the adrenal, pituitary, and thyroid glands.

Symplex F is a dietary supplement, and it doesn’t need FDA approval. Please note that the FDA does not monitor adrenal extract supplements in the pill form and won’t intervene until dangers are identified.

You can contact the Standard Process customer service by calling at 800-558-8740 or email

No, this supplement is not recommended to children.

The company’s manufacturing processes are certified as organic by MOSA, guaranteeing that ingredients remain organic from seed to supplement.

According to the information available on the official website, the company is committed to the health-giving properties of whole food nutrition. It is using ingredients that have not been genetically modified.


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