SeroVital Advanced Review – The Best HGH Supplement or Market Hype?

This review is medically reviewed or fact checked to ensure factually accurate information.

With strict editorial sourcing guidelines, we only link to reputable media sites, academic research institutions and, when research is available, medically peer-reviewed studies. Note that an extensive list with all used Sources is available at the end of the review.

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SeroVital Advanced is an anti-aging HGH supplement for smoother skin, immune support, restful sleep, improved digestion, enhanced focus, improved mood, and increased energy. Both men and women can use this product.

At the moment of this SeroVital Advanced review, ads promoting this HGH (Human Growth Hormone) supplement are everywhere: on TV, social media, in magazines, in newspapers, and celebrities can’t stop talking about it.

But does SeroVital really work? Is this the miraculous anti-aging dietary supplement SanMedica International claims it to be?

Read our in-depth SeroVital Advanced review and find out if this supplement is for you or not.

Quick Overview

SeroVital Advanced is one of the most popular anti-aging supplements available in the United States. HGH supplements for anti-aging are getting increasingly popular; however, like most products out there, this dietary supplement is primarily a combination of different amino acids.

While many amino acids have been clinically proven to enhance HGH production in the body, this enhancing effect is relatively minimal. It doesn’t last long because of the body’s homeostasis system. 

That’s why HGH products that “prolong” the effect of amino acids by using an anti-somatostatin blend of ingredients like Phosphatidylcholine and Alpha GPC are better working to increase HGH. 

SeroVital Advanced doesn’t incorporate any of these two key ingredients.

Who Makes It?

SeroVital Advanced is made by SanMedica International, an American business located in Salt Lake City, Utah. The company produces various health and beauty products like BeLashFull, Skin Restore, Under Eye Rescue, Hair Regeneres, and Restore & Renew

However, their most popular product line is SeroVital in its three variants: Anti-Aging (the basic formula), HGH (take-anyway powder form), and Advanced (the more complex formulation).

SanMedica International contact details:

  • Address: 5742 W Harold Gatty Dr, Salt Lake City, UT 84116-3777
  • Phone: 800-435-1409
  • Website:

SeroVital Advanced Ingredients

SeroVital Advanced contains the following active ingredients per serving (four yellow capsules, one red capsule, and one white capsule): 

Renewal Complex Blend 2.9 g (yellow capsules)

  • L-Arginine Hydrochloride
  • L-Lysine Hydrochloride
  • N-Acetyl L-Cysteine
  • Oxo-Proline
  • L-Glutamine
  • Schizonepeta (aerial parts) powder

Inactive ingredients in yellow capsules include silicon dioxide, riboflavin (color), gelatin, rice flour, magnesium stearate, stearic acid, microcrystalline cellulose, titanium dioxide, and candurin silver fine.

Proprietary Blend 1,016 mg (red and white capsules)

  • Chlorella (broken cell) [source of Chlorella Growth Factor]
  • Coffee (bean) extract
  • Olive (leaf) extract
  • Lady’s Mantle (leaf) extract
  • Cumin (seed) extract
  • Smart Release purified Japanese Glucomannan [Konjac (root) extract]
  • Wild Mint (leaf) extract
  • Collagen Peptides
  • Triticum aestivum (seed) extract (source of Ceramides)
  • Hyaluronic acid (as sodium hyaluronate)
  • Keratin Peptides

The red and white capsules also contain the following vitamins and minerals:

  • Vitamin C (as ascorbic acid) 22 mg
  • Selenium (as l-selenomethionine) 60 mcg
  • Riboflavin (Vitamin B2) 30 mg
  • Vitamin D (as cholecalciferol) 33 mcg
  • Zinc (as zinc gluconate) 14 mg
  • Copper (as copper gluconate) 0.9 mg

Inactive ingredients in red and white capsules include microcrystalline cellulose, dicalcium phosphate, magnesium stearate, hypromellose, croscarmellose sodium, silicon dioxide, stearic acid, hydroxypropyl cellulose, titanium dioxide, tricalcium phosphate, polyethylene glycol, polydextrose, vegetable juice (color), talc, maltodextrin, and medium-chain triglycerides.

Are Amino Acids Enough?

L-lysine, L-arginine, Oxo-Proline, N-Acetyl L-Cysteine, and L-Glutamine are essential or conditionally essential amino acids that are not produced by the human body or are in limited amounts.

Amino acid supplements have been found to raise serum HGH levels, but only at very high doses (likely higher than what’s in SeroVital Advanced) or when taken without exercise.

These types of supplements can also increase HGH levels, but only in the short-term.

L-Arginine is useful in producing nitric oxide, a compound that relaxes the blood vessels and increases blood circulation. According to several clinical pieces of research, oral L-arginine ingestion and growth hormone increases are linked. 

Participants in these studies have received high amounts of L-Arginine (up to 1200 mg) and smaller L-lysine amounts. Furthermore, in some cases, the HGH levels did not increase until the dosage of L-Arginine was increased to up to 9 g (9,000 mg). This is at least three times the amount that SeroVital Advanced contains.

L-Lysine is commonly used to support protein production and the immune system. L-Lysine is also believed to improve athletic performance as it increases GHG levels naturally. These L-Lysine benefits are backed by clinical evidence showing that when Arginine and Lysine are combined and taken orally, it improves the insulin and pituitary somatotropin (HGH) release. 

However, the benefits were noticeable only at high doses of both Lysine and Arginine. 

Browsing SeroVital’s official website or only looking at the label, there is no mention of how much of any specific amino acid actually is in the formula. 

Assuming SeroVital Advanced is a lot like Growth Factor 9 (another HGH based performance booster that uses precisely the same SeroVital formula and ingredients). SeroVital Advanced likely contains 2.9 g (2,900 mg) of ALL ingredients combined.

Oxo-Proline is synthesized from glutamic acids. Limited clinical trials conducted on animals showed that Oxo-Proline might reduce the non-enzymatic antioxidant defenses in the brain and cause “reactive species production.” In short, the oxo-proline may have some harmful effects.

Basically, Oxo-Proline may draw out oxidative stress or cause discrepancies among reactive oxygen and the body’s capability to repair damaged cells. It produces toxic effects through the production of free radicals. Concisely, supplementing with this amino acid may damage every cell part, including DNA, proteins, and lipids.

L-Glutamine operates as a buffer, preventing catabolism and soreness of muscle. Research shows that HGH conserves muscle-free glutamine stores, enhancing the body’s ability to work longer and harder. This also is an excellent ingredient in SeroVital Advanced.

Studies have shown that L-Glutamine may increase the body’s ability to work harder for longer. Bodybuilders and athletes use Glutamine-based dietary supplements because of the endurance this amino acid provides and how it keeps cortisol (stress hormone) in check without adverse effects.

Interestingly, this amino acid is also used as a “stress buster” because of its excellent properties to handle mental and physical stress. 

N-Acetyl L-Cysteine (NAC) functions as a potent antioxidant. Initially, it attaches to and neutralizes the free radicals. Afterward, it promotes the mixture of Glutathione (an endogenous antioxidant). This is a more stable Cysteine form, which can be turned into Cysteine in the cell.

Whereas N-Acetyl L-Cysteine might help counteract the oxidative effects of Oxo-Proline, there is insufficient research to prove any impact on HGH production. However, NAC has some extraordinary anti-aging, antioxidant, and anti-inflammatory benefits. Men using this supplement have also experienced more energy, vigor, and higher testosterone levels.

How Much Does SeroVital Advanced Cost?

SeroVital Advanced is available for purchase in three variants and the price varies depending on the variant you want:

  • SeroVital Anti-Aging – $99 (120 capsules / 30 servings)
  • SeroVital HGH – $99 (30 sachets box / 30 servings)
  • SeroVital Advanced – $119 (120 capsules + 30 tablets / 30 servings)

SanMedica offers an autoship (VIP) option for those who want to receive the product every month. There is a $20 discount on autoship for all three variants.

Where To Buy SeroVital Advanced?

This amino acid supplement is widely available at numerous online retailers (Amazon, Costco, Walmart, eBay, CVS, Groupon, ShopHQ, etc.) and in almost every store across the United States.

SeroVital Advanced Review – Pros & Cons


  • A much safer amino acids-based formulation when compared to HGH injections;
  • Some claimed benefits are backed by valid clinical research;
  • May support smoother skin, the immune system, restful sleep, digestion, focus, mood, and energy;
  • 30 days money-back guarantee;
  • Hormone-free formula.


  • Expensive at $119 per box (30 day supply);
  • Mixed reviews;
  • Is missing some essential ingredients that any HGH supplement should have – Alpha GPC, PhosphatidylCholine, GABA, Colostrum (bovine Source), and deer antler velvet;
  • It contains Oxo-Proline, a potentially dangerous and not enough researched substance.

Claimed Benefits

According to SanMedica International, the SeroVital product line offers a wide range of benefits in both men and women. These benefits may include:

  • Increased energy;
  • Better mood;
  • Improved sleep;
  • Reduced body fat;
  • Strengthen bones;
  • Heighten sex drive;
  • Tighten skin and reduce wrinkles.

SeroVital Advanced Side Effects & Warnings

Unlike synthetic HGH injections, SeroVital’s amino acid-based formula is likely devoid of potentially dangerous adverse effects.

In fact, that’s why SanMedica doesn’t merely use amino acids in large amounts (similar to the doses used in clinical studies analyzing the benefits of specific amino acids on HGH production). 

Large amounts of amino acids like L-Lysine and L-Arginine may lead to:

  • Acne
  • Vertigo
  • Swelling of hands and feet
  • Achy joints
  • Headaches
  • Heartburn
  • Nausea
  • Fatigue

Customer Testimonials

This is a good product, it works, and I have been taking it for over two years. Originally I purchased it from the company SeroVital directly.

I haven’t seen an increased libido mentioned anywhere in the reviews, but I’ve been taking this for 13 days, and I noticed a HUGE increase in my libido after […] Read full review

I have been taking this product for three months. I take it as directed with no food besides water two hours prior and two hours after taking the supplements. I have seen no change in my skin, hair, mood, and weight. The red and white pills can […] Read full review


If you are looking for some alternatives to SeroVital Advanced, you might want to consider some of the options below.

Glutathione, made by Nature’s Craft, is a natural anti-aging supplement for both men and women. The formula contains 500 mg of Glutathione, known for skin whitening benefits, for improving skin health, and for its potent anti-aging properties. Glutathione also is a powerful antioxidant since it supports the function of other antioxidants in the body. This helps prevent signs of aging and fight oxidative damage.

Imedeen Time Perfection, made by Imedeem, is another popular anti-aging beauty supplement. Several variants are available for a complete treatment regime. Imedeen also offers a variant for men, designed to improve skin quality and structure, reduce visible signs of aging, protect skin against harmful UV rays, and improve skin’s moisture balance.

Collagen Advanced with Vitamin C, made by Youtheory, is one of the best selling collagen supplements on the market. According to Youtheory, their unique formula supports healthy sleep, weight, energy, skin, and mood. The product is inexpensive compared with other similar beauty supplements at just $11.99 for 120 tablets / 20 servings. 


There’s a lot of hype around this product. However, despite what you might on TV or on social media, SeroVital Advanced is NOT endorsed by Dr. Oz. His name has been used around this product to generate “hype” and to lend it credibility.

That being said, SeroVital Advanced definitely is a better alternative to HGH injections. As most of its formula consists of amino acids, it’s unlikely to lead to severe adverse effects, making it a much safer alternative to many other HGH products. 

So is it worth it?

If you’re not interested in getting your body subjected to extensive HGH treatments, and if you can afford the $100+ monthly cost for this supplement, it may be worth giving SeroVital Advanced a try.

Frequently Asked Questions

Yes, unlike synthetic HGH injections, SeroVital’s amino acids-based formula is likely devoid of potentially dangerous adverse effects.

SeroVital is widely available at numerous online retailers (Amazon, Costco, Walmart, eBay, CVS, Groupon, ShopHQ, etc.) and almost every store across the United States.

SeroVital is a dietary supplement and does not require premarket approval from the FDA.

This amino acid supplement is made by SanMedica International.

SeroVital Advanced reviews on Amazon, as of February 2021, are positive, with 74% of the customers ranking this supplement with four (4) stars or higher. Out of 514 customer reviews, here’s how this nootropic supplement ranks: 

  • 5 star – 64%
  • 4 star – 10%
  • 3 star – 11%
  • 2 star – 4%
  • 1 star – 11%

SeroVital Advanced builds on the original SeroVital Anti-Aging formula. It has everything that the original formula has, plus several added benefits that are not contained in SeroVital Anti-Aging – expressly, two tablets that promote great skin and weight loss.


  • SanMedica International official website. Retrieved on February 2, 2021. [Source]
  • Human growth hormone (HGH): Does it slow aging? – Published on May 14, 2020. Retrieved on February 2, 2021. [Source]
  • New Study Finds Remarkable Benefits of SeroVital Consumption – Published on May 27, 2019. Retrieved on February 2, 2021. [Source]
  • A. Isidori, A. Lo Monaco, and M. Cappa – A study of growth hormone release in man after oral administration of amino acids. Published in 1981. Retrieved on February 2, 2021. [Source]
  • Carolina Didonet Pederzolli, Caroline Paula Mescka, Bernardo Remuzzi Zandoná, Daniella de Moura Coelho, Angela Malysz Sgaravatti, Mirian Bonaldi Sgarbi, Angela Terezinha de Souza Wyse, Clóvis Milton Duval Wannmacher, Moacir Wajner, Carmen Regla Vargas, and Carlos Severo Dutra-Filho – Acute administration of 5-oxoproline induces oxidative damage to lipids and proteins and impairs antioxidant defenses in cerebral cortex and cerebellum of young rats. Published in June 2010. Retrieved on February 2, 2021. [Source]
  • Emily Cronkleton – Side Effects of hGH: What You Should Know. Retrieved on February 2, 2021. [Source]
  • Human Growth Hormone (HGH) – Retrieved on February 2, 2021. [Source]
  • Growth hormone, athletic performance, and aging – Harvard Medical School. Published in May 2010. Retrieved on February 2, 2021. [Source]
  • Luke Bucci, James F. Hickson Jr., James M. Pivarnik, Ira Wolinsky, John C. McMahon, and Stewart D.Turner – Ornithine ingestion and growth hormone release in bodybuilders. Published in March 1990. Retrieved on February 2, 2021. [Source]
  • R. R. Suminski, R. J. Robertson, F. L. Goss, S. Arslanian, J. Kang, S. DaSilva, A. C. Utter, and K. F. Metz – Acute effect of amino acid ingestion and resistance exercise on plasma growth hormone concentration in young men. Published in March 1997. Retrieved on February 2, 2021. [Source]
  • T. C. Welbourne – Increased plasma bicarbonate and growth hormone after an oral glutamine load. Published in May 1995. Retrieved on February 2, 2021. [Source]
  • K. Kasai, M. Kobayashi, and S. I. Shimoda – Stimulatory effect of glycine on human growth hormone secretion. Published in February 1978. Retrieved on February 2, 2021. [Source]
  • Sung-Hwa Sohn, Sunim Cho, Eun Seok Ji, Sung-Hoon Kim, Minkyu Shin, Moochang Hong, and Hyunsu Bae – Microarray analysis of the gene expression profile of HMC-1 mast cells following Schizonepeta tenuifolia Briquet treatment. Published in June 2012. Retrieved on February 2, 2021. [Source]

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1 Comment. Leave new

  • Jamie M Petimezas
    March 26, 2021 1:43 pm

    Been taking seroVital for 5 months now with no benefits at all. Was really giving it a chance, but I’m finally giving up and also file a complaint with the BBB


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